The action of the series take place in the Little Tokyo (Edoropolise) - a town where the traditional meets the futuristic.The town is inhabited by a variety of anthropomorphic animals of flesh and blood, many of which, however, are part of cybernetic tela.Ofitsialno, the governor of Tokyo is the Lesser Emperor Fred. But after his wisdom teeth were removed, he went mad. Therefore,Little Tokyo in reality controlled by the Emperor`s daughter Princess Vi and consul. Behind the consul is Prime Minister Seymour "Big " Cheese, who constantly tries to overthrow the Princess and the consul, thus becoming the Emperor Small Tokio.Tolko Dvortsovskoy Guard commander - Al Dente - knows the secret treacherous plans of the Big Cheese.However, due to lack of evidence, his only option - to prevent the execution of Seymour plans. For this, he hires three young warriors cats, Samurai Pizza Cats. Each of them has its own skills and weapons that will help them protect the citizens of Small Tokyo, usually from giant robots Seymour Cheese.